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重要文件

44270

Sigma-Aldrich

反式反式-法尼基焦磷酸 铵盐

≥95.0% (HPLC)

同義詞:

法尼基二磷酸酯 铵盐, (E,E)-3,7,11-三甲基-2,6,10-十二碳三烯-1-基焦磷酸盐 铵盐

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About This Item

經驗公式(希爾表示法):
C15H28O7P2 · xNH3
分子量::
382.33 (free acid basis)
Beilstein:
2482197
分類程式碼代碼:
12352212
PubChem物質ID:
NACRES:
NA.25
暫時無法取得訂價和供貨情況

等級

for analytical purposes

化驗

≥95.0% (HPLC)

形狀

solid

儲存溫度

−20°C

SMILES 字串

N.C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O

InChI

1S/C15H28O7P2.H3N/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18;/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18);1H3/b14-9+,15-11+;

InChI 密鑰

CPYJTMLHKIWGDF-NDHHSALASA-N

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相關類別

應用

法尼基二磷酸铵盐可用于研究称为法呢基化的翻译后过程,其用于修饰重要蛋白质,例如Ras癌基因。

生化/生理作用

法尼基焦磷酸盐是更复杂的倍半萜类化合物、萜类化合物和类固醇[1]的生物合成中的关键中间体,并且 FPP 和相应的醇法尼醇具有不同生物学功能[2][3][4][5][6][7]。FPP 在 Ras 蛋白的翻译后加工中起重要作用。Ras 的突变形式与人类癌症相关,因此在癌症研究中进行了研究[5][6]

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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S M Sebti et al.
Oncogene, 19(56), 6584-6593 (2001-06-28)
In 1990, more than 10 years after the discovery that the low molecular weight GTPase Ras is a major contributor to human cancer, farnesylation, a lipid posttranslational modification required for the cancer-causing activity of Ras, emerged as a major target
Farnesyl Diphosphate Analogues with Aryl Moieties Are Efficient Alternate Substrates for Protein Farnesyltransferase.
Subramanian T, Pais JE, Liu S, et al.
Biochemistry (2012)
Po-Huang Liang et al.
European journal of biochemistry, 269(14), 3339-3354 (2002-07-24)
In this review, we summarize recent progress in studying three main classes of prenyltransferases: (a) isoprenyl pyrophosphate synthases (IPPSs), which catalyze chain elongation of allylic pyrophosphate substrates via consecutive condensation reactions with isopentenyl pyrophosphate (IPP) to generate linear polymers with
Roman Shchepin et al.
Chemistry & biology, 10(8), 743-750 (2003-09-05)
The dimorphic fungus Candida albicans produces extracellular farnesol (3,7,11-trimethyl-2,6,10-dodecatriene-1-ol) which acts as a quorum-sensing molecule (QSM) to suppress filamentation. Of four possible geometric isomers of farnesol, only the E,E isomer possesses QSM activity. We tested 40 natural and synthetic analogs
R J Hohl et al.
Lipids, 33(1), 39-46 (1998-02-21)
This investigation compares the effects of three farnesyl pyrophosphate analogs on selected aspects of isoprenoid metabolism. E,E-alpha-Hydroxyfarnesylphosphonate was prepared by an improved variation on a literature synthesis, which also gave access to the new Z,E-alpha-hydroxyfarnesyl- and alpha-hydroxygeranylphosphonates. A striking find

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