424M-1

CITED1 (5H6) Mouse Monoclonal Antibody

• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100; 500
• 共軛: unconjugated
• 抗體表格: ascites fluid
• 抗體產品種類: primary antibodies
• 無性繁殖: 5H6, monoclonal
• 描述: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• 形狀: buffered aqueous solution
• 物種活性: human
• 包裝: vial of 0.1 mL concentrate (424M-14); vial of 0.5 mL concentrate (424M-15); bottle of 1.0 mL predilute (424M-17); vial of 1.0 mL concentrate (424M-16); bottle of 7.0 mL predilute (424M-18)
• 製造商／商標名: Cell Marque^®
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• 同型: IgG2aκ
• 控制: Wilms’ tumor
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C
• 視覺化: nuclear
• 基因資訊: human ... CITED1(4435)

描述

一般說明

CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.^1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.³ Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.¹ CITED1 expression has been shown to persist in blastemal cell populations of human WT.^1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.^1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.¹ CITED1 has been detected in 86.8% of WT Cases.²

品質

IVD

IVD

IVD

RUO

聯結

CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: [email protected]

法律資訊

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany