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Merck
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重要文件

410R-1

Sigma-Aldrich

Cytokeratin 10 (EP97) Rabbit Monoclonal Primary Antibody

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.41
暫時無法取得訂價和供貨情況

生物源

rabbit

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP97, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (410R-14)
vial of 0.5 mL concentrate (410R-15)
bottle of 1.0 mL predilute (410R-17)
vial of 1.0 mL concentrate (410R-16)
bottle of 7.0 mL predilute (410R-18)

製造商/商標名

Cell Marque®

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

同型

IgG

控制

squamous cell carcinoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic

基因資訊

human ... KRT10(3858)

一般說明

Cytokeratin 10 (CK10) belongs to type I and acidic keratin family.[1] It is low molecular weight keratin that is usually expressed in suprabasal keratinocytes and can also be seen in suprabasal cells of internal noncornifying, stratified squamous epithelia.[1]In addition, CK10 is reported to be a typical component of cells of eccrine sweat gland ducts and sebaceous cells.[2]Anti-CK10 is helpful in the identification of well differentiated squamous cell carcinoma derived from skin or from internal organs.[2][3]However, CK10 was found to be sparse in poorly differentiated squamous cell carcinoma, even though it has been reported that focal CK10 expression has been found in 50% of cases of oral and pharyngeal squamous cell carcinoma.[3]Anti-CK10 has demonstrated utility in the differentiation of extra-mammary Paget′s disease (negative) from basal cell carcinoma and squamous cell carcinoma (positive).[3]

品質


IVD

IVD

IVD

RUO

聯結

Cytokeratin 10 Positive Control Slides, Product No. 410S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: [email protected]

法律資訊

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Roland Moll et al.
Histochemistry and cell biology, 129(6), 705-733 (2008-05-08)
The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed
Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors.
R Moll
Sub-cellular biochemistry, 31, 205-262 (1999-02-05)
Ichiro Kurokawa et al.
Experimental dermatology, 20(3), 217-228 (2011-02-18)
Keratins are a highly diverse family of cytoskeletal proteins and important markers of epithelial cell differentiation. In this review, applying the new keratin nomenclature recently introduced, we summarize and discuss the distribution and significance of keratin patterns in cutaneous epithelial

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