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Merck
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重要文件

40674

Sigma-Aldrich

松脂醇

≥95.0% (HPLC)

同義詞:

(+)-松脂醇, 4,4′-((1S,3aR,4S,6aR)-六氢呋喃[3,4-c]呋喃-1,4-二基)双(2-甲氧基苯酚), 4,4′-[(1S,3aR,4S,6aR)-四氢-1H,3H-呋喃[3,4-c]呋喃-1,4-二基]双(2-甲氧基苯酚) )

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About This Item

經驗公式(希爾表示法):
C20H22O6
CAS號碼:
分子量::
358.39
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.25
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化驗

≥95.0% (HPLC)

形狀

powder or crystals

應用

metabolomics
vitamins, nutraceuticals, and natural products

SMILES 字串

COc1cc(ccc1O)[C@H]2OC[C@H]3[C@@H]2CO[C@@H]3c4ccc(O)c(OC)c4

InChI

1S/C20H22O6/c1-23-17-7-11(3-5-15(17)21)19-13-9-26-20(14(13)10-25-19)12-4-6-16(22)18(8-12)24-2/h3-8,13-14,19-22H,9-10H2,1-2H3/t13-,14-,19+,20+/m0/s1

InChI 密鑰

HGXBRUKMWQGOIE-AFHBHXEDSA-N

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一般說明

Pinoresinol is a secondary metabolite, a lignan found in wide varieties of plants.[1] Structurally, it is one of the simple lignans, with a dimer of coniferyl alcohol, which forms the bicyclic ring core.[1]

應用

Pinoresinol has been used:
  • as a reference standard for qualitative and quantitative analysis of lignans from Triticale (X Triticosecale Wittmack) grains using ultra-performance liquid chromatography (UPLC) with photodiode and mass TQD detectors[2]
  • as an enterolignan precursor to study its estrogenic activity on the proliferation of human breast cancer MCF-7 cells[3]
  • as a reference standard for lignan analysis of Sesamum indicum L. seeds[4]

生化/生理作用

松脂素存在于包括药用植物在内的多种植物中,如水生接骨木、杜仲、安息香属、连翘以及特级初榨橄榄油中。其中的接骨木属广泛分布于欧洲、亚洲和北非,并已在传统医学中作为止痛药、抗病毒药、抗炎药、止血药和利尿药用于瘀伤、骨折和水肿。松脂素可通过引起真菌质膜的损伤而显示出有效的抗真菌特性。它通过抑制TNF-α的产生(很可能是通过抑制NF- κB和AP-1)而发挥出抗氧化和抗炎的作用。
通过抑制TNF-α的产生而发挥出抗氧化和抗炎的作用。

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Frank C Schroeder et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(42), 15497-15501 (2006-10-13)
Pinoresinol, a lignan of wide distribution in plants, is found to occur as a minor component in the defensive secretion produced by glandular hairs of caterpillars of the cabbage butterfly, Pieris rapae. The compound or a derivative is appropriated by
Kishan Chandra et al.
Biotechnology reports (Amsterdam, Netherlands), 22, e00336-e00336 (2019-04-25)
Members of Cytochromes P450 super family of enzymes catalyse important biochemical reactions in plants. Some of these reactions are so important that they contribute to enormous chemical diversity seen in plants. Many unique secondary metabolites formed by mediation of these
Lignans in triticale grain and triticale products
Makowska A, et al.,
Journal of Cereal Science, 93, 102939-102939 (2020)
Yun Zhu et al.
PloS one, 12(2), e0171390-e0171390 (2017-02-06)
Mammalian lignans or enterolignans are metabolites of plant lignans, an important category of phytochemicals. Although they are known to be associated with estrogenic activity, cell signaling pathways leading to specific cell functions, and especially the differences among lignans, have not
Hyo Won Jung et al.
Neuroscience letters, 480(3), 215-220 (2010-07-06)
The activation of microglia plays an important role in a variety of brain disorders by the excessive production of inflammatory mediators such as nitric oxide (NO), prostaglandin E(2) (PGE(2)) and proinflammatory cytokines. We investigated here whether pinoresinol isolated from the

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