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27655

Sigma-Aldrich

Colistin sodium methanesulfonate

from Bacillus colistinus

同義詞:

Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate

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About This Item

經驗公式（希爾表示法）:
C58H115N16Na5O28S5
CAS號碼:
8068-28-8
分子量：:
1759.90
EC號碼:
232-516-9
MDL號碼:
MFCD00130824
分類程式碼代碼:
51102829
PubChem物質ID:
57648263
NACRES:
NA.85
暫時無法取得訂價和供貨情況

生物源

Bacillus colistinus

形狀

powder or crystals

燃燒殘留物

~20%

損耗

≤5.0% loss on drying

顏色

white to off-white

pH值

6.5-8.5

抗生素活性譜

Gram-negative bacteria

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O

InChI

1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1

InChI 密鑰

WSDSONZFNWDYGZ-BKFDUBCBSA-I

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一般說明

Chemical structure: peptide

應用

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.

生化／生理作用

Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity[1] Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect [2].
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.

包裝

1g, 5g

其他說明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000422746
0000422746
0000397383
0000397384
0000389315

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Roberto Imberti et al.
Chest, 138(6), 1333-1339 (2010-06-19)
Infections caused by multidrug-resistant gram-negative bacteria have caused a resurgence of interest in colistin. To date, information about pharmacokinetics of colistin is very limited in critically ill patients, and no attempts have been made to evaluate its concentration in BAL.
M.J. Rogers et al.
Infection (Munich), 14, 79-79 (1986)
Matthew E Falagas et al.
Expert review of anti-infective therapy, 6(5), 593-600 (2008-10-14)
Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative
Nikolaos Markou et al.
The Journal of antimicrobial chemotherapy, 67(10), 2459-2462 (2012-07-14)
Available data on colistin pharmacokinetics in patients undergoing continuous renal replacement therapy (CRRT) are limited. Our aim was to study colistin pharmacokinetics in critically ill patients treated with colistin methane sulphonate for Gram-negative sepsis and undergoing continuous venovenous haemodiafiltration for
Lidia Dalfino et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54(12), 1720-1726 (2012-03-17)
Gram-negative bacteria susceptible only to colistin (COS) are emerging causes of severe nosocomial infections, reviving interest in the use of colistin. However, consensus on the most effective way to administer colistin has not yet been reached. All patients who had
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Questions

  1. For how long can product 27655 (Colistin Sodium Methanesulfonate) be stored at RT in powder form before loosing any efficacy? Can you provide any RT storage stability/efficacy data?

    1 answer

    1. The stability of Product 27655, Colistin Sodium Methanesulfonate, if stored at ambient temperature is not determined.

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