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22049

Sigma-Aldrich

λ-角叉菜胶

plant mucopolysaccharide

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About This Item

CAS號碼:
9064-57-7
EC號碼:
232-953-5
MDL號碼:
MFCD00151513
分類程式碼代碼:
12352201
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

plant

形狀

solid

顏色

light yellow

儲存溫度

room temp

InChI

1S/C24H42O39S6/c25-1-5-9(27)11(29)18(61-67(42,43)44)22(54-5)57-15-8(4-52-65(36,37)38)56-23(19(13(15)31)62-68(45,46)47)59-16-10(28)6(2-26)55-24(20(16)63-69(48,49)50)58-14-7(3-51-64(33,34)35)53-21(32)17(12(14)30)60-66(39,40)41/h5-32H,1-4H2,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)/p-6/t5-,6-,7-,8-,9+,10+,11+,12+,13+,14+,15+,16+,17-,18-,19-,20-,21+,22+,23-,24+/m1/s1

InChI 密鑰

CFLYIPGVTFOQCI-SQESNNFJSA-H

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一般說明

以1%浓度溶于0.2M KCl溶液中时，为非凝胶状态
角叉菜胶是来自红藻细胞壁的粘多糖。 它们是由1,3α-1,4β-半乳聚糖组成的阴离子线性聚合物，每个二糖单元具有一个（κ-）、两个（ι-）或三个（λ-）硫酸盐。 在离子溶液中，κ-和ι-角叉菜胶自缔合成螺旋结构，分别形成刚性或柔性凝胶。 λ-角叉菜胶不会形成螺旋结构并且是非凝胶化的。 角叉菜胶被用作商业增稠剂和稳定剂。

應用

角叉菜胶被用于在 体内 和 体外 实验中抑制通过巨噬细胞选择性细胞病变效应机制而产生的免疫应答。非凝胶状态的λ-角叉菜胶被用于诱导啮齿动物后爪炎症和炎性疼痛或气囊炎症模型。 最近，角叉菜胶被直接注射到啮齿动物的关节中，模拟关节炎疼痛和炎症。

分析報告

溶解度：
在H2O中为10 mg/mL：清澈至非常模糊，无色至淡黄色

其他說明

为了全面了解我们针对客户研究提供的各种多糖产品，建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
BCBP8978V
BCBP7001V
BCBP3274V
BCBP3273V
BCBN6085V

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Refat M Hassan et al.
Carbohydrate research, 346(14), 2260-2267 (2011-08-30)
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Vanessa Pirrone et al.
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Continued efforts are being directed toward the development of microbicides that will be used to reduce or eliminate the risk of HIV-1 sexual transmission. Unfortunately, clinical trials involving polyanion-containing microbicide formulations, including Carraguard (λ-carrageenan [LC]) and Ushercell (cellulose sulfate [CS])
Tamara Barahona et al.
Carbohydrate research, 347(1), 114-120 (2011-12-16)
The water soluble polysaccharide produced by the green variant of tetrasporic Gigartina skottsbergii was found to be composed of D-galactose and sulfate groups in a molar ratio of 1.0:0.65. (1)H and (13)C NMR spectroscopy studies of the desulfated polysaccharide showed
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can you give me information about the molecular weight of lambda carrageenan?

    1 answer

    1. The molecular weight is not determined for this product. However, the literature states that the molecular weight for lambda Carrageenan is 446 kDa (number average) and 990 kDa (weight average) by ICP-AES (inductively coupled plasma-atomic emission spectrometry.

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