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Merck
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文件

19176

Sigma-Aldrich

DL -丁硫氨酸亚砜亚胺

≥99.0% (TLC)

同義詞:

DL-Buthionine (S,R)-sulfoximine, BSO, Buthionine sulfoximine, Butionine sulfoximine

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About This Item

經驗公式(希爾表示法):
C8H18N2O3S
CAS號碼:
分子量::
222.31
Beilstein:
2367136
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic

化驗

≥99.0% (TLC)

形狀

powder or crystals

mp

215 °C

溶解度

H2O: 50 mg/mL, clear to almost clear, colorless

儲存溫度

2-8°C

SMILES 字串

CCCCS(=N)(=O)CCC(N)C(O)=O

InChI

1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)

InChI 密鑰

KJQFBVYMGADDTQ-UHFFFAOYSA-N

應用

DL-丁硫氨酸-亚砜亚胺适用于:
  • 检测 BSO 抑制谷胱甘肽是否增强雌激素对抗激素抵抗性人乳腺癌细胞的凋亡作用
  • 研究 BSO 对牛胚胎发育的影响
  • 在多项研究中抑制 GSH
  • GSH 合成对卵母细胞成熟的影响
可用于抑制 GSH,评价天然食用色素在缺乏 GSH 时的肝、肾毒性

生化/生理作用

丁硫氨酸亚砜亚胺抑制肝脏和其他外周器官谷胱甘肽 (GSH) 的生物合成。对 CNS 中 GSH 无任何影响。增强活性氧(如过氧化氢)和间接引起活性氧蓄积的药物(如 2-甲氧基雌二醇,增加细胞内超氧阴离子)操作抗增殖作用。

其他說明

耗尽分离细胞中的谷胱甘肽

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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M Takahashi et al.
Biology of reproduction, 49(2), 228-232 (1993-08-01)
The purpose of this investigation was to determine the effect of beta-mercaptoethanol (beta-ME) and cysteamine, low-molecular-weight thiol compounds, on the development and intracellular glutathione content of bovine embryos obtained by in vitro fertilization of in vitro-matured oocytes. Embryos developed to
N Yamauchi et al.
Biology of reproduction, 61(3), 828-833 (1999-08-24)
The present study was conducted to examine effects of cysteamine in culture medium on progression of meiosis, glutathione (GSH) content, kinase activities (histone H1 kinase and mitogen-activated protein kinase), and male pronuclear formation after in vitro insemination of cumulus-denuded oocytes
Jong-Shyan Wang et al.
European journal of applied physiology, 95(4), 290-297 (2005-08-13)
Exercise is linked with intensity-dependent immune response. Intracellular redox status is important in programmed cell death. This study, by closely examining 18 sedentary men who exercised moderately and severely (ie. 60% and 80% VO2max, respectively) for 40 min, investigated how
A Slivka et al.
Journal of neurochemistry, 50(5), 1391-1393 (1988-05-01)
Previous studies indicated that DL-buthionine sulfoximine (DL-BSO), an agent that inhibits the biosynthesis of GSH in liver and other peripheral organs, fails to suppress levels of GSH in the CNS. In the current study, preweanling mice responded to repeated injections
Yuka Hirai et al.
Biological & pharmaceutical bulletin, 29(5), 1064-1067 (2006-05-03)
2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, induces the intracellular accumulation of superoxide anion (O2*-) and buthionine sulfoximine (BSO) is an inhibitor of glutathione (GSH) synthesis. We have examined the combination anticancer effect of 2-ME and BSO accompanied with hydrogen

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