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重要文件

17944

Sigma-Aldrich

1α,25-二羟维生素 D2

≥97.0% (sum of vitamin and previtamin, HPLC)

同義詞:

1α,25-二羟骨化醇

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About This Item

經驗公式(希爾表示法):
C28H44O3
CAS號碼:
分子量::
428.65
Beilstein:
5635017
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.79
暫時無法取得訂價和供貨情況

生物源

synthetic

化驗

≥97.0% (sum of vitamin and previtamin, HPLC)

形狀

crystals

顏色

white to light yellow

儲存溫度

−70°C

SMILES 字串

C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C

InChI

1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1

InChI 密鑰

ZGLHBRQAEXKACO-XJRQOBMKSA-N

生化/生理作用

麦角钙化醇(维生素 D2)在体内 通过羟基化活化为 25-羟基麦角钙化醇和 1α,25-二羟基骨化醇。活化的维生素 D2 分子可用于广泛的研究,以评估其对免疫功能和钙稳态等功能的影响。

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Hanna Baurska et al.
Oncology reports, 28(3), 1110-1116 (2012-07-04)
1,25-Dihydroxyvitamin D3 (1,25D) is implicated in many cellular functions including cell proliferation and differentiation, thus, exerting potential antitumor effects. A major limitation for therapeutic use of 1,25D are its potent calcemic and phosphatemic activities. Therefore, synthetic analogs of 1,25D for
Yuki Nagata et al.
Endocrine, 40(2), 315-317 (2011-08-09)
N-terminal propeptide of type I procollagen (PINP) is a marker of newly formed type I collagen. However, its role in hypophosphatemic rickets/osteomalacia has not yet been established. Metabolic bone markers were examined in patients with oncogenic osteomalacia (OOM) and X-linked
Qing Wang et al.
Journal of cellular biochemistry, 89(6), 1087-1101 (2003-08-05)
Recent studies revealed that the MEK/ERK module of the mitogen-activated protein kinase (MAPK) signaling cascades is up-regulated in the early stages of 1alpha,25-dihydroxyvitamin D(3) (1,25D(3))-induced monocytic differentiation of human leukemia cells HL60. In the present study, we investigated whether another
Joanna Wietrzyk et al.
Oncology research, 16(11), 517-525 (2008-03-01)
New vitamin D analogs are interesting candidates for anticancer treatment, including squamous cell carcinomas (SCCs), especially in combination with cytostatics. In order to evaluate the effect of combined application of cisplatin, imatinib, or docetaxel and new vitamin D analogs [PRI-1906:
Shigeaki Kato et al.
Current opinion in nephrology and hypertension, 16(4), 297-304 (2007-06-15)
Vitamin D has diverse biological actions, and consequently the mechanisms behind how it regulates gene transcription are diverse. Unlike its well described positive effects on gene transcription, little is known about how vitamin D induces transcriptional repression. Vitamin D-induced transcriptional

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