推薦產品
生物源
synthetic
品質等級
化驗
≥95%
形狀
solid
儲存條件
under inert gas
技術
HPLC: suitable
顏色
white to off-white
儲存溫度
−20°C
SMILES 字串
[N+]([O-])(CCC=C1c2c(cccc2)CCc3c1cccc3)(C)C
InChI
1S/C20H23NO/c1-21(2,22)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
InChI 密鑰
ZPMKQFOGINQDAM-UHFFFAOYSA-N
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一般說明
Amitriptyline N-oxide is the N-oxidation metabolite of the antidepressant amitriptyline
應用
Metabolomics research
其他說明
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訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Thomas Altendorfer-Kroath et al.
Journal of neuroscience methods, 311, 394-401 (2018-09-30)
Assessment of drug concentration in the brain interstitial fluid (ISF) is crucial for development of brain active drugs, which are mainly small, lipophilic substances able to cross the blood-brain barrier (BBB). We aimed to compare the applicability of cerebral Open
Judith M Kampa et al.
Toxicology letters, 325, 43-50 (2020-02-25)
As a consequence of the detoxification process, drugs and drug related metabolites can accumulate in the liver, resulting in drug induced liver injury (DILI), which is the major cause for dose limitation. Amitriptyline, a commonly used tricyclic anti-depressant, is known
Ursula Breyer-Pfaff
Drug metabolism reviews, 36(3-4), 723-746 (2004-11-24)
Amitriptyline (AT), the most widely used tricyclic antidepressant, undergoes oxidative metabolism in the side chain with production of the secondary amine nortriptyline (NT), a primary amine, and the N-oxide amitriptylinoxide (AT-NO); in addition, direct conjugation leads to a quaternary ammonium-linked
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