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Merck
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文件

P5654

Sigma-Aldrich

吡罗昔康

≥98% (TLC)

同義詞:

2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物

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About This Item

經驗公式（希爾表示法）:
C15H13N3O4S
CAS號碼:
36322-90-4
分子量：:
331.35
EC號碼:
252-974-3
MDL號碼:
MFCD00057317
分類程式碼代碼:
41116107
PubChem物質ID:
24278641
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

100

化驗

≥98% (TLC)

形狀

powder

儲存溫度

2-8°C

SMILES 字串

CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

InChI 密鑰

QYSPLQLAKJAUJT-UHFFFAOYSA-N

基因資訊

human ... PTGS1(5742) , PTGS2(5743)
rat ... Alox5(25290)

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應用

吡罗昔康已用于：
  • 诱发小鼠结肠炎
  • 作为非类固醇抗炎药，提高白介素-10(IL-10)敲除小鼠对肠道损伤的敏感性
  • 研究其作为化学预防试剂和阳性对照，对小鼠小肠肿瘤生长的影响

生化／生理作用

吡罗昔康(Piroxicam)是非类固醇抗炎药(NSAID)。具有镇痛活性，对风湿病有治疗作用。
环加氧酶抑制剂。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險聲明

H301,H373

危險分類

Acute Tox. 3 Oral - STOT RE 2 Oral

標靶器官

Gastrointestinal tract

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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分析證明 (COA)

Lot/Batch Number
0000374811
0000374583
0000374811
0000374583
0000336293

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Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Lang M, et al.
Molecular Cancer, 12(1), 41-41 (2013)
Jiawei Guo et al.
Cell reports. Medicine, 4(1), 100881-100881 (2023-01-06)
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) with unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium and IL-10 knockout induced with piroxicam, bone mass and quality are significantly decreased.
Seung-Won Choi et al.
Plant biotechnology (Tokyo, Japan), 39(3), 323-327 (2022-11-10)
Agrobacterium-mediated transformation is a key innovation for plant breeding, and routinely used in basic researches and applied biology. However, the transformation efficiency is often the limiting factor of this technique. In this study, we discovered that oxicam-type nonsteroidal anti-inflammatory drugs
T J Carty et al.
Prostaglandins, 19(1), 51-59 (1980-01-01)
The new non-steroidal antiinflammatory (NSAI)2 agent, piroxicam [4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide], is a highly active inhibitor of prostaglandin (PG) synthesis by methylcholanthrene transformed mouse fibroblasts (MC5-5) and rabbit synovial cells in culture. Comparison of the PG biosynthesis inhibitory activity of piroxicam with
Michaela Lang et al.
Molecular cancer, 12(1), 41-41 (2013-05-15)
Patients with familial adenomatous polyposis (FAP) are at increased risk for the development of colorectal cancer. Surgery and chemoprevention are the most effective means to prevent cancer development. Thymoquinone (TQ) is considered the main compound of the volatile Nigella sativa
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