BP720

维拉帕米 盐酸盐

British Pharmacopoeia (BP) Reference Standard

• 同義詞: （±）-维拉帕米 盐酸盐, 5-[N-（3，4-二甲氧基苯基乙基）甲胺基]-2-（3，4-二甲氧基苯基）-2-异丙基戊腈α； 盐酸盐
• 線性公式: (CH₃O)₂C₆H₃CH₂CH₂N(CH₃)(CH₂)₃C[C₆H₃(OCH₃)₂][CH(CH₃)₂]CN · HCl
• CAS號碼: 152-11-4
• 分子量：: 491.06
• Beilstein: 3647093
• MDL號碼: MFCD00055208
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: pharmaceutical primary standard
• API 家族: verapamil
• 形狀: solid
• 儲存期限: limited shelf life, expiry date on the label
• 製造商／商標名: BP
• mp: 142 °C (dec.) (lit.)
• 應用: pharmaceutical; pharmaceutical small molecule
• 格式: neat
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
• InChI: 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
• InChI 密鑰: DOQPXTMNIUCOSY-UHFFFAOYSA-N
• 基因資訊: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

描述

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Verapamil hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Verapamil Prolonged-release Tablets

Verapamil Tablets

Verapamil Oral Solution

Verapamil Prolonged-release Capsules

Verapamil Injection

生化／生理作用

α₁-肾上腺素受体拮抗剂；L型钙通道阻滞剂。阻断平滑肌和心肌中的 L 型 Ca²⁺ 通道，体外诱导人原发性和转移性结肠癌细胞的凋亡。对 PGP 起作用的抗药性逆转剂，如减少肾小管清除地高辛。增加 Pgp 的基础 ATP 酶活性。Cyp3A4 和 CYP2C6 的底物。

包裝

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他說明

Sales restrictions may apply.

安全資訊

• 象形圖: GHS06,GHS09
• 訊號詞: Danger
• 危險聲明: H301,H411
• 防範說明: P264 - P273 - P301 + P310 - P391 - P405 - P501
• 危險分類: Acute Tox. 3 Oral - Aquatic Chronic 2
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable