917605

2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride

≥95%

• 同義詞: Semi-flexible linker for PROTAC^® development
• 經驗公式（希爾表示法）: C₁₃H₁₈ClNO₂
• CAS號碼: 34033-52-8
• 分子量：: 255.74
• 分類程式碼代碼: 12352106
• NACRES: NA.22

屬性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• 反應適用性: reagent type: linker
• 官能基: carboxylic acid
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(CC(C=C1)=CC=C1C2CCNCC2)O.Cl

描述

應用

2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

其他說明

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable