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71478

Supelco

Nα-(2,4-二硝基-5-氟苯基)-L氨基丙酰胺

for chiral derivatization, LiChropur, ≥99.0%

同義詞:

FDAA, Marfey 试剂

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About This Item

經驗公式(希爾表示法):
C9H9FN4O5
CAS號碼:
分子量::
272.19
Beilstein:
6820069
MDL號碼:
分類程式碼代碼:
12000000
PubChem物質ID:
NACRES:
NA.22
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等級

derivatization grade ((chiral))
for chiral derivatization

品質等級

化驗

≥99.0% (sum of enantiomers, TLC)
≥99.0%

形狀

powder

光學活性

[α]20/D +56±2°, c = 1% in acetone

光學純度

enantiomeric ratio: ≥99.5:0.5 (HPLC)

品質

LiChropur

技術

HPLC: suitable

儲存溫度

2-8°C

SMILES 字串

C[C@H](Nc1cc(F)c(cc1[N+]([O-])=O)[N+]([O-])=O)C(N)=O

InChI

1S/C9H9FN4O5/c1-4(9(11)15)12-6-2-5(10)7(13(16)17)3-8(6)14(18)19/h2-4,12H,1H3,(H2,11,15)/t4-/m0/s1

InChI 密鑰

NEPLBHLFDJOJGP-BYPYZUCNSA-N

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一般說明

Nα-(2,4-二硝基-5-氟苯基)-L-丙氨酰胺(FDAA)是一种手性衍生剂(CDA),与其他CDA相比具有高对映选择性和低灵敏度。它常被用于指定痕量氨基酸的立体化学。[1]

應用

在一项使用反相高效液相色谱-电喷雾电离质谱(RPHPLC-ESI-MS)了解罕见氨基酸的研究中,FDAA被用作衍生化试剂。[1]

其他說明

检测非常规手性 α-氨基酸类似物的衍生化试剂[2]

推薦產品

探索最适于 HPLCLC-MS分析的LiChropur试剂

法律資訊

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Chirality determination of unusual amino acids using precolumn derivatization and liquid chromatography-electrospray ionization mass spectrometry.
Hess S
Journal of Chromatography A, 1035(2), 211-219 (2004)
Evan W Rogers et al.
Journal of natural products, 68(6), 891-896 (2005-06-25)
The absolute configurations of fistularin-3, 11-epi-fistularin-3, and a related bis-oxazolidinone were determined by microscale hydrolysis followed by derivatization with 1-fluoro-2,4-dinitrophenyl-5-l-alaninamide. Samples of fistularin-3 from Verongid marine sponges collected in the Great Barrier Reef (Australia), Baía de Todos os Santos (Brazil)
D R Goodlett et al.
Journal of chromatography. A, 707(2), 233-244 (1995-07-21)
A high-performance liquid chromatography-electrospray ionization-mass spectrometric (LC-ESI-MS) method is presented that allows rapid and accurate determination of amino acid chiral purity in a peptide. Peptides are hydrolyzed in hydrochloric acid-d1/acetic acid-d4 and then converted to diastereomers by derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine
E Harth-Fritschy et al.
The journal of peptide research : official journal of the American Peptide Society, 50(6), 415-420 (1998-01-24)
Esterification of glycosylated serine and cysteine derivatives with a 4-alkoxybenzyl alcohol (Wang) resin is described. The classical methods of ester bond formation (symmetrical anhydride, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate [TBTU]/4-dimethylaminopyridine [DMAP] with or without 1-hydroxybenzotriazole [HOBT], pentafluorophenyl [Pfp] esters gave high percentages of
D B Goodnough et al.
Journal of chromatography. B, Biomedical applications, 672(2), 290-294 (1995-10-20)
D-Serine has recently been described to be present in the brain at high concentrations. However, while prior research has demonstrated that L-phosphoserine is the major precursor of L-serine in the brain, the possible role of D-phosphoserine as the direct precursor

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