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Merck
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重要文件

35391

Supelco

Triclabendazole sulfoxide

VETRANAL®, analytical standard

同義詞:

5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole

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About This Item

經驗公式(希爾表示法):
C14H9Cl3N2O2S
CAS號碼:
分子量::
375.66
Beilstein:
5829656
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
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等級

analytical standard

品質等級

產品線

VETRANAL®

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)

形式

neat

SMILES 字串

CS(=O)c1nc2cc(Cl)c(Oc3cccc(Cl)c3Cl)cc2[nH]1

InChI

1S/C14H9Cl3N2O2S/c1-22(20)14-18-9-5-8(16)12(6-10(9)19-14)21-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

InChI 密鑰

GABQPFWIQFRJSE-UHFFFAOYSA-N

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一般說明

Triclabendazole sulfoxide belongs to the benzimidazole class of anthelmintics drugs.[1][2] It is very much effective against mature and immature stages of Fasciola hepatica and Fasciola gigantica in all ruminant species.[2]

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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法律資訊

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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M Meaney et al.
Parasitology research, 88(4), 315-325 (2002-05-10)
The effect of the active sulphoxide metabolite of the fasciolicide triclabendazole on the surface morphology of the tropical liver fluke, Fasciola gigantica, was determined in vitro by scanning electron microscopy. At a concentration of 10 microg/ml, swelling and blebbing of
Mark W Robinson et al.
Parasitology research, 92(3), 205-210 (2003-12-04)
Benzimidazole anthelmintics are widely used against nematode, cestode and trematode parasites. The drugs undergo several enzyme-mediated reactions within the host animal that produce a number of metabolites. Although it has been shown that certain helminths, including Fasciola hepatica, can metabolise
G Virkel et al.
Journal of veterinary pharmacology and therapeutics, 29(3), 213-223 (2006-05-04)
Triclabendazole (TCBZ) is an halogenated benzimidazole (BZD) compound worldwide used to control immature and adult stages of the liver fluke Fasciola hepatica. The purpose of this investigation was to characterize in vitro the patterns of hepatic and ruminal biotransformation of
F Imperiale et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 28(4), 438-445 (2011-02-22)
Triclabendazole (TCBZ) is a flukicidal halogenated benzimidazole compound extensively used in veterinary medicine. Liver fluke control in lactating dairy cattle is difficult because treatment should be implemented only during the dry period to avoid milk residues. However, control in endemic
L Halferty et al.
Veterinary parasitology, 159(2), 126-138 (2008-11-26)
A study has been carried out to determine the relative activity of triclabendazole (TCBZ) and its sulphoxide (TCBZSO) and sulphone (TCBZSO(2)) metabolites against the adult stage of the liver fluke, Fasciola hepatica. Flukes were incubated for 24h in vitro in

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