33894

克霉唑

VETRANAL^®, analytical standard

• 同義詞: 1-[（2-氯苯基）二苯基甲基]-1-H咪唑, 1-（o-氯-α，α-二苯基苄基）咪唑, 1-（o-氯三苯）咪唑
• 經驗公式（希爾表示法）: C₂₂H₁₇ClN₂
• CAS號碼: 23593-75-1
• 分子量：: 344.84
• EC號碼: 245-764-8
• MDL號碼: MFCD00057220
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329754531
• NACRES: NA.24

屬性

• 等級: analytical standard
• 產品線: VETRANAL^®
• 儲存期限: limited shelf life, expiry date on the label
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 抗生素活性譜: fungi
• 應用: agriculture; environmental
• 形式: neat
• 作用方式: protein synthesis | interferes
• SMILES 字串: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• InChI 密鑰: VNFPBHJOKIVQEB-UHFFFAOYSA-N

描述

一般說明

Clotrimazole, a non-toxic, systemic, imidazole derivative[1] with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.[2][3]

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.[4]

應用

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams[1] and ear drops[5] by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.[5]

Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:

• Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).[6]
• Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).[4]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法律資訊

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H410
• 防範說明: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves