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Key Documents

22128

Sigma-Aldrich

Cefotaxime sodium salt 钠盐

≥98.0% (TLC)

同義詞:

Cefotaxim sodium salt 钠盐

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About This Item

經驗公式(希爾表示法):
C16H16N5NaO7S2
CAS號碼:
分子量::
477.45
Beilstein:
5711411
EC號碼:
MDL號碼:
分類程式碼代碼:
51101500

化驗

≥98.0% (TLC)

雜質

≤5% water

溶解度

H2O: 50 mg/mL, clear, light yellow

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

InChI 密鑰

AZZMGZXNTDTSME-JUZDKLSSSA-M

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一般說明

Chemical structure: ß-lactam

生化/生理作用

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

其他說明

Broad spectrum third generation cephalosporin antibiotic.

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Laetitia Betelli et al.
Talanta, 184, 210-218 (2018-04-21)
The accurate identification of β-lactamases produced by Enterobacteriaceae is a major challenge in clinical laboratories in order to optimize antimicrobial treatment and patient care. We describe here a rapid voltammetric-based method to detect and to discriminate β-lactamase activity in Enterobacteriaceae
Carola E H Rosenkilde et al.
Nature communications, 10(1), 618-618 (2019-02-08)
Antibiotic resistance is a major challenge to global public health. Discovery of new antibiotics is slow and to ensure proper treatment of bacterial infections new strategies are needed. One way to curb the development of antibiotic resistance is to design

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