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06655

Sigma-Aldrich

(R)-(-)-1-氨基乙基膦酸

≥97.0% (NT)

同義詞:

L-(-)-1-氨基乙基膦酸, L-Ala(P)

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About This Item

線性公式:
CH3CH(NH2)P(O)(OH)2
CAS號碼:
分子量::
125.06
Beilstein:
4291032
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.22
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化驗

≥97.0% (NT)

光學活性

[α]20/D −4.8±0.5°, c = 5% in H2O

儲存溫度

2-8°C

SMILES 字串

C[C@H](N)P(O)(O)=O

InChI

1S/C2H8NO3P/c1-2(3)7(4,5)6/h2H,3H2,1H3,(H2,4,5,6)/t2-/m1/s1

InChI 密鑰

UIQSKEDQPSEGAU-UWTATZPHSA-N

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一般說明

(R)-(-)-1-Aminoethylphosphonic acid is a synthetic analog of L-alanine that shows antibacterial property.

應用

(R)-(−)-1-Aminoethylphosphonic acid can be used to prepare copper(II) heteroligand complexes, which are employed in the solution equilibrium studies.[1]

其他說明

在"P 端"具有此氨基酸类似物的二肽至四肽是青霉素类和脑脂质类的杀菌剂和协同增效剂[2][3][4]

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Reaction of Alanine Racemase with 1-Aminoethylphosphonic Acid Forms a Stable External Aldimine
Stamper CGF, et al.
Biochemistry, 37(29), 10438-10445 (1998)
Stabilities and coordination modes of α-alaninephosphonic acid in copper (II) heteroligand complexes with ethylenediamine, diethylenetriamine or N, N, N′, N′, N″-pentamethyldiethylene triamine in aqueous solution
Kamecka A, et al.
Journal of Solution Chemistry, 40(6), 1041-1054 (2011)
F R Atherton et al.
Antimicrobial agents and chemotherapy, 15(5), 677-683 (1979-05-01)
Peptide mimetics with C-terminal residues simulating natural amino acids have been designed as inhibitors of bacterial cell wall biosynthesis. The phosphonopeptide series consisting of various l and d residues of natural amino acids combined with 1-aminoalkyl (and aryl-alkyl-) phosphonic acid
J G Allen et al.
Antimicrobial agents and chemotherapy, 16(3), 306-313 (1979-09-01)
The metabolism and pharmacokinetics of a synthetic antibacterial phosphonodipeptide, alafosfalin, have been studied in rats, baboons, and human volunteers. The compound was rapidly absorbed from the injection site after subcutaneous and intramuscular administration and gave peak plasma concentrations at 15
Phosphonopeptides, a new class of synthetic antibacterial agents.
J G Allen et al.
Nature, 272(5648), 56-58 (1978-03-02)

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