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Merck
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文件

03394

Sigma-Aldrich

聚(乙二醇)

tested according to Ph. Eur., 6,000

同義詞:

Macrogol 6,000, PEG

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About This Item

線性公式:
H(OCH2CH2)nOH
CAS號碼:
MDL號碼:
分類程式碼代碼:
12352104
PubChem物質ID:
NACRES:
NA.21

agency

tested according to Ph. Eur.

品質等級

形狀

solid

分子量

5000-7000

溶解度

aliphatic hydrocarbons: slightly soluble
organic solvents: soluble

應用

pharmaceutical (small molecule)

SMILES 字串

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI 密鑰

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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應用

聚乙二醇用于将西罗莫司固体分散体纳米粒作为亲水性载体进行表征。

生化/生理作用

聚乙二醇 (PEG) 是环氧乙烷和水的缩聚物。增强提取蛋白的复性。 这使得结晶蛋白的表征成为可能。

準備報告

聚乙二醇可溶于许多有机溶剂,易溶于芳香烃。也微溶于脂肪烃。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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J L Cleland et al.
The Journal of biological chemistry, 267(19), 13327-13334 (1992-07-05)
Polyethylene glycol (PEG) inhibited aggregation during refolding of bovine carbonic anhydrase B (CAB) through the formation of a nonassociating PEG-intermediate complex. Stoichiometric concentrations of PEG were required for complete recovery of active protein during refolding at aggregating conditions. For example
J L Cleland et al.
Bio/technology (Nature Publishing Company), 10(9), 1013-1019 (1992-09-01)
Previous studies on the refolding of recombinant bovine carbonic anhydrase B (CAB) indicated that polyethylene glycol (PEG) significantly enhanced the recovery of active protein by reducing aggregation. To further test the ability of PEG to enhance refolding, three recombinant human
Min-Soo Kim et al.
International journal of nanomedicine, 6, 2997-3009 (2011-12-14)
The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS) process. First, excipients for enhancing the stability and solubility of
I L Konorova et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (4)(4), 7-9 (1991-07-01)
The search for antiaggregatory compounds is undertaken, as a rule, under in vitro conditions which do not reflect the dynamics of the real process. The present work deals with study of the peculiarities of the development of the collagen induced
Idalis Villanueva et al.
Acta biomaterialia, 5(8), 2832-2846 (2009-06-11)
The pericellular matrix (PCM) surrounding chondrocytes is thought to play an important role in transmitting biochemical and biomechanical signals to the cells, which regulates many cellular functions including tissue homeostasis. To better understand chondrocytes interactions with their PCM, three-dimensional poly(ethylene

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