推薦產品
化驗
≥98% (HPLC)
形狀
lyophilized
分子量
calculated mol wt 797.82
包裝
pkg of 1 mg
製造商／商標名
Millipore
儲存條件
desiccated
protect from light
技術
cell based assay: suitable
顏色
green
運輸包裝
ambient
儲存溫度
−20°C
一般說明
Increasing evidence suggests that a small population of tumor initiating cells (TIC) or cancer stem cells (CSC) are responsible for tumorigenesis and resistance to conventional anti-cancer therapies. Heme oxygenase 2 (HMOX2) has recently been identified as a novel biomarker for tumor initiating cells. BioTracker TiNIR HMOX2 Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and isolation of HMOX2 expressing tumor initiating cells. At low concentrations or a single injection of high concentration, TiNIR (tumor initiating cell probe with near infrared) is useful for the isolation of TIC in vitro and in vivo visualization in tumor model animals, respectively. At high concentrations or repeated treatments, TiNIR has been shown to inhibit the function of HMOX2 and induce tumor cell death by accumulating ROS in cancer cells .
Spectral Properties
Absorbance: 805 nm
Emission: 825 nm
Reference:1. Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.
Spectral Properties
Absorbance: 805 nm
Emission: 825 nm
Reference:1. Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.
應用
Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
特點和優勢
Near-Infrared probe for detection and isolation of HMOX2 expressing tumor initiating cells.
外觀
Lyophilized. Green solid.
儲存和穩定性
Store at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
其他說明
Live cell fluorescent imaging
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Jong-Jin Kim et al.
Journal of the American Chemical Society, 141(37), 14673-14686 (2019-08-23)
Tumor initiating cells (TIC) are resistant to conventional anticancer therapy and associated with metastasis and relapse in cancer. Although various TIC markers and their antibodies have been proposed, it is limited to the use of antibodies for in vivo imaging
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