MABT911F

Anti-Tspan-33 Antibody, clone 29A6.2 Antibody, FITC conjugate

clone 29A6.2, from mouse, FITC conjugate

• 同義詞: Tetraspanin-33, Penumbra, mPen, Proerythroblast new membrane
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

屬性

• 生物源: mouse
• 共軛: FITC conjugate
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 29A6.2, monoclonal
• 物種活性: human, mouse
• 包裝: antibody small pack of 25 μL
• 技術: flow cytometry: suitable
• 同型: IgMκ
• NCBI登錄號: NP_666285.1
• UniProt登錄號: Q8R3S2
• 目標翻譯後修改: unmodified
• 基因資訊: mouse ... Tspan33(232670)

描述

一般說明

Tetraspanin-33 (UniProt: Q8R3S2; also known as Tspan-33, Penumbra, mPen, Proerythroblast new membrane) is encoded by the Tspan33 (also known as Pen) gene (Gene ID: 232670) in murine species. Tetraspanins are evolutionarily conserved proteins and thus far 33 of them have been described in human and murine species. Tspan-33 is a multi-pass, disulfide-linked homodimeric membrane protein of the tetraspanin (TM4SF) family. It has been reported that Tspan-33 is highly expressed in activated B cells. Its expression has also been reported in malignant B cells. Two isoforms of Tspan-33 have been described that are produced by alternative splicing. Tspan-33 plays an important role in normal erythropoiesis and in the differentiation of erythroid progenitors. Tspan-33 contains four transmembrane domains (aa 25-45, 65-85, 97-117, 236-256), three cytoplasmic domains (aa 1-24, 86-96, 257-283), and two extracellular domains (aa 46-64, 118-235). Several tetraspanins interact with specific membrane proteins via their second extracellular domain (aa 118-235) and incorporate them into tetraspanin-enriched microdomains to modulate the effectiveness of signal transduction by those membrane proteins. (Ref.: Luu, VP., et al. (2013). Clin. Immunol. 149(3): 388-399).

特異性

Clone 29A6.2 specifically detects Tspan-33 and targets an epitope with in the extracellular domain.

免疫原

BaF3 cells expressing full-length murine Tspan-33 fused with a Myc-His tag at the C-terminus.

Epitope: extracellular domain

應用

Anti-Tspan-33, clone 29A6.2, FITC conjugate, Cat. No. MABT911F, is a mouse monoclonal antibody that detects Tetraspanin-33 and has been tested for use in Flow Cytometry.

Research Category
Cell Structure

品質

Evaluated by Flow Cytometry in mouse splenocytes.

Flow Cytometry Analysis: 0.5 µg of this antibody detected Tspan-33 in 500,000 cells per mL mouse splenocytes.

標靶描述

31.55 kDa calculated.

外觀

Protein G purified

Purified mouse monoclonal antibody IgM in PBS with 0.1% sodium azide, with 1.5% BSA.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.