MABN643

Anti-NDUFS3 Antibody, clone 6H7.1

clone 6H7.1, from mouse

• 同義詞: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial, Complex I-30kD, CI-30kD, NADH-ubiquinone oxidoreductase 30 kDa subunit
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 6H7.1, monoclonal
• 物種活性: rat, human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_004542
• UniProt登錄號: O75489
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... NDUFS3(4722)

描述

一般說明

NDUFS3 is the core subunit of the mitochondrial respiratory chain′s NADH dehydrogenase complex, also known as Complex I, the complex critical for the production of ATP and NADH electron transfer. In mammals Complex I consists of some 45 different proteins, NDUFS3 is the critical core subunit of the complex. Expressed in all cells and localized in the mitochondria but encoded by a nuclear gene, NDUFS3 plays a critical role in electron transport, our internal cellular respiratory chain, and mitochondrial function. NDUFS3 also is important in disease phenotypes and various cancers. Mutations in NDUFS3 give rise to Leigh syndrome a mitochondrial dysfunctional disease. In cancers, down regulation of NDUFS3 is linked with lowered host survival and increased cancer pathology.

免疫原

GST-tagged recombinant protein corresponding to human NDUFS3.

應用

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected NDUFS3 in human cerebral cortex, rat hippocampus, and rat cerebellum tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-NDUFS3 Antibody, clone 6H7.1 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of NDUFS3.

品質

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected NDUFS3 in 200 µg of THP-1 cell lysate.

標靶描述

~30 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable