MABC567

Anti-Somatoliberin/GHRH Antibody, clone 1B4.2

clone 1B4.2, from mouse

• 同義詞: Somatoliberin, Growth hormone-releasing factor, GRF, Growth hormone-releasing hormone, GHRH, Somatocrinin, Somatorelin, Sermorelin, Somatoliberin/GHRH
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 1B4.2, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_001171660
• UniProt登錄號: P01286
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified

描述

一般說明

The human GHRH (also known as GHRF) gene (Gene ID 2691) encodes the 108 aa Somatoliberin preproprotein (UniProt P01286; also known as GHRH, GRF, Growth hormone-releasing factor, Growth hormone-releasing hormone, INN: Sermorelin, Sermorelin, Somatocrinin, Somatorelin). Post-translatioinal removal of the signal peptide (aa 1-20) and the two propeptide sequences (aa 21-31 and aa 76-108) releases the 44 aa mature Somatoliberin (aa 32-75) that functions as a ligand to stimulate growth hormone (GH) release from the pituitary. Variant GHRH receptors are found in several types of tumors. Antagonists against such receptors are reported to inhibit tumors growth. Defects in GHRH gene cause dwarfism and hypersecretion of somatoliberin is linked to gigantism.

特異性

Clone 1B4.2 is expected to detect prepro-, pro-, and mature somatoliberin.

免疫原

Epitope: Mature somatoliberin

KLH-conjugated linear peptide corresponding to mature human somatoliberin sequence.

應用

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Somatoliberin/GHRH in human cerebral cortex tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-Somatoliberin Antibody, clone 1B4.2 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GHRH .

品質

Evaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Somatoliberin/GHRH in 10 µg of human lung tissue lysate.

標靶描述

~12 kDa observed. Preprosomatoliberin (12.4 kDa calculated); Prosomatoliberin (10.9 kDa calculated); Mature somatoliberin (10.4 kDa calculated). Uncharacterized band(s) may appear in some lysates.

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable