ABT48
Anti-Vesicle protein sorting 35 (VPS35) Antibody
from rabbit
同義詞:
vacuolar protein sorting 35 homolog (S. cerevisiae), vacuolar protein sorting 35, Maternal-embryonic 3, vacuolar protein sorting 35 (yeast homolog), vacuolar protein sorting 35 (yeast), Vesicle protein sorting 35
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About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
暫時無法取得訂價和供貨情況
生物源
rabbit
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
human, rat, mouse
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... VPS35(55737)
一般說明
Vacuolar protein sorting-associated protein 35 (VPS35) is critical component found within the retromer complex. The retromer complex is comprised of several proteins and has been implicated in roles involving the Wnt signaling pathway, cell migration and adhesion, and polymeric immunoglobulin A transcytosis. VPS35 plays an essential role in the selection and trafficking of lysosomal enzyme receptors from endosomes to the Golgi. It is also a required component for the secretion of active Wnt. Expression of VPS35 is pervasive throughout all tissue. Highest levels of expression have been observed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, spleen, testis, and thymus.
免疫原
GST-tagged recombinant protein corresponding to human VPS35.
應用
Anti-Vesicle protein sorting 35 (VPS35) Antibody is an antibody against Vesicle protein sorting 35 (VPS35) for use in WB.
RNAi: A previous lot of antibody was used in siRNA knockdown experiments by an independent laboratory (Courtesy of Gomez, TS, Mayo Clinic, 2010).
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
品質
Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected VPS35 in 10 µg of A431 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected VPS35 in 10 µg of A431 cell lysate.
標靶描述
~ 80 kDa observed MW. Expected MW is 92 kDa
外觀
Protein G
Format: Purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
A431 cell lysate
A431 cell lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Elpida Tsika et al.
Human molecular genetics, 23(17), 4621-4638 (2014-04-18)
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the
Mian Cao et al.
Neuron, 93(4), 882-896 (2017-02-24)
Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic vesicle endocytosis to the dephosphorylation of PI(4,5)P2, a reaction needed for the shedding of endocytic factors from their membranes. While the role of SJ1's 5-phosphatase module in this process
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