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重要文件

ABN2300C3

Sigma-Aldrich

Neuro-Chrom Pan Neuronal Marker Antibody-Rabbit, Cy3 Conjugate

Neuro-Chrom, from rabbit

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
暫時無法取得訂價和供貨情況

生物源

rabbit

品質等級

共軛

CY3 conjugate

無性繁殖

polyclonal

物種活性

mouse, rat

製造商/商標名

Neuro-Chrom

技術

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

運輸包裝

wet ice

目標翻譯後修改

unmodified

一般說明

Antibodies to neuronal proteins have become critical tools for identifying neurons and discerning morphological characteristics in culture and complex tissue. While the labeling from classic histological techniques such as Golgi staining and modern molecular approaches such as GFP constructs yield excellent cytoarchitectural detail, these approaches are technically challenging and impractical for many neuroscience research needs. Neuron-specific antibodies are convenient precision tools useful in revealing cytoarchitecture, but are limited to the protein target distribution within the neuron, which may differ greatly from nucleus to soma to dendrite and axon. To achieve as complete a morphological staining as possible across all parts of neurons, Millipore has developed a polyclonal antibody blend that reacts against key somatic, nuclear, dendritic, and axonal proteins distributed across the pan-neuronal architecture that can then be detected by a single secondary antibody. This antibody cocktail has been validated in diverse methods, cell culture and immuno-histochemistry, giving researchers a convenient and specific qualitative and quantitative tool for studying neuronal morphology.

特異性

Cat. # ABN2300C is specific to axons (neurites), dendrites, nucleus, and the cell body of neurons.
Reactivity with other species has not been determined.

免疫原

Epitope: Whole Neuron Marker

應用

Neuro-Chrom Pan Neuronal Marker-Rabbit, Cy3 Conjugate is an antibody targeting the Pan Neuronal Marker protein, validated for use in ICC, IHC & IF.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

品質

Routinely tested Rat E18 cortex primary neurons in Immunocytochemistry.

外觀

Polyclonal antibody cocktail blend conjugated to Cy3 in PBS buffer with 15mg/mL BSA and 0.05% NaN3

儲存和穩定性

Maintain at 2-8°C for up to 1 year from date of receipt.

分析報告

Control
Rat E18 cortex primary neuron cell culture or mouse adult brain cryosections.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Paul S Baxter et al.
Cell reports, 34(12), 108882-108882 (2021-03-25)
Microglia, brain-resident macrophages, require instruction from the CNS microenvironment to maintain their identity and morphology and regulate inflammatory responses, although what mediates this is unclear. Here, we show that neurons and astrocytes cooperate to promote microglial ramification, induce expression of
Zoeb Jiwaji et al.
Nature communications, 13(1), 135-135 (2022-01-12)
Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPTP301S tauopathy mice revealed that only Aß influenced expression of AD risk genes, but both
Cayla E Jewett et al.
eLife, 12 (2023-01-20)
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related molecules and pathways, and the

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