ABC848

Anti-Toso Antibody

from rabbit, purified by affinity chromatography

• 同義詞: Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso, Toso
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 技術: western blot: suitable
• UniProt登錄號: O60667
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FAIM3(9214)

描述

一般說明

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. Toso (also known as Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis and FAIM3) is a novel regulator of Fas-induced apoptosis in lymphoid cells and when overexpressed in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to a 13 amino acid peptide near the C-terminus of human Toso.

應用

Anti-Toso Antibody is a highly specific rabbit polyclonal antibody, that targets Fas apoptotic inhibitory molecule 3 & has been tested in western blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in human lung tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected Toso in human lung tissue lysate with and without blocking peptide.

標靶描述

~60 kDa observed.
Despite its predicted molecular weight of 43 kDa, Toso often migrates at 60 kDa in western blots.
Uncharacterized bands may be observed in some lysate(s).

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable