ABC428

Anti-VEGF-D Antibody

1 mg/mL, from rabbit

• 同義詞: Vascular endothelial growth factor D, VEGF-D, c-Fos-induced growth factor, FIGF
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: rat (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology)
• 濃度: 1 mg/mL
• 技術: western blot: suitable
• NCBI登錄號: NP_004460
• UniProt登錄號: O43915
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FIGF(2277)

描述

一般說明

VEGF-D, also known as Vascular Endothelial Growth Factor D, or c-Fos-induced growth factor, FIGF, and encoded by the gene FIGF/VEGFD, is one of a family of vascular growth factors that is active in angiogenesis, lymphangiogenesis and endothelial cell growth. VEGF-D functions during the formation of venous and lymphatic vascular systems and is critical for their maintenance during adulthood. VEGF-D, originally discovered as a c-Fos induced growth factor (FIGF), is developmentally regulated by c-Fos and expressed in a variety of tissues and organs including limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column. Because of its role in lymphangiogenesis VEGFD is also a key therapeutic target to modulate metastasis, and recent research demonstrates that VEGFD-MEK-ERK signaling modulates SOX18-mediated transcription in normal cells and thus various pathologies maybe because of a dysregulation of SOXF-mediated transcriptional networks.

免疫原

Epitope: Near N-terminus

KLH-conjugated linear peptide corresponding to human VEGF-D near the N-terminus.

應用

Anti-VEGF-D Antibody detects level of VEGF-D & has been published & validated for use in VEGF-D.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in SW620 cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected VEGF-D in 10 µg of SW620 cell lysate.

標靶描述

~57 kDa observed. The calculated molecular weight is 40 kDa, however VEGF-D has been shown as a ~57 to ~58 kDa band in western blots (Liu Y.H., et al., (2008) J Immunol. 81(9):6584-94).

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1