8.52418

Fmoc-Asp(OBno)-OH

for peptide synthesis, Novabiochem^®

• 同義詞: Fmoc-Asp(OBno)-OH
• 經驗公式（希爾表示法）: C₃₂H₄₃NO₆
• 分子量：: 537.69
• 分類程式碼代碼: 12352209
• NACRES: NA.22

屬性

• 產品名稱: Fmoc-Asp(OBno)-OH, Novabiochem^®
• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: powder
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 官能基: carboxylic acid
• 儲存溫度: −20°C (−15°C to −25°C)

描述

一般說明

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS, including those containing the Asp-Gly sequence. The bulky OBno protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu and OMpe group.^[1],[2]

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aspartimide Formation in Fmoc SPPS

Literature references:
^[1] R. Behrendt, et al. (2015) J. Pept. Sci., 21, 680.
^[2] R. Behrendt, et al. (2016) J. Pept. Sci., 22, 92.

應用

Recently, Fmoc-Asp(OBno)-OH has been used in the synthesis of the mini-protein Omomyc, which has been shown to repress MYC-dependent gene transcription.[3],[4]

分析報告

Color (visual): white to beige
Appearance of substance (visual): powder, chunks or crystals
Identity (IR): passes test
Purity (TLC (018A)): ≥ 95 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable