8.52189

Fmoc-Tyr(tBu)-Ser(psiMe,Mepro)-OH

≥97.0% (HPLC), for peptide synthesis, Novabiochem^®

• 同義詞: Fmoc-Tyr(tBu)-Ser(psiMe,Mepro)-OH
• 經驗公式（希爾表示法）: C₃₄H₃₈N₂O₇
• CAS號碼: 878797-09-2
• 分子量：: 586.67
• MDL號碼: MFCD11974986
• 分類程式碼代碼: 12352209
• NACRES: NA.22

屬性

• 產品名稱: Fmoc-Tyr(tBu)-Ser(psiMe,Mepro)-OH, Novabiochem^®
• 品質等級: 200
• 產品線: Novabiochem^®
• 化驗: ≥95% (TLC); ≥97.0% (HPLC)
• 形狀: powder
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 官能基: hydroxyl
• 儲存溫度: 2-8°C
• SMILES 字串: N5([C@@H](COC5(C)C)C(=O)O)C(=O)[C@@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)Cc1ccc(cc1)OC(C)(C)C
• InChI: 1S/C34H38N2O7/c1-33(2,3)43-22-16-14-21(15-17-22)18-28(30(37)36-29(31(38)39)20-42-34(36,4)5)35-32(40)41-19-27-25-12-8-6-10-23(25)24-11-7-9-13-26(24)27/h6-17,27-29H,18-20H2,1-5H3,(H,35,40)(H,38,39)/t28-,29-/m0/s1
• InChI 密鑰: DNJYPUYQFPFOKS-VMPREFPWSA-N

描述

一般說明

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Tyr-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

聯結

Replaces: 05-20-1014

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -49.0 - -42.0 °
Purity (TLC(157A)): ≥ 95 %
Purity (TLC(CMA2)): ≥ 95 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Ethyl acetate (HS-GC): ≤ 2.0 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable