682160-M

Xestospongin C, Xestospongia sp.

An oxaquinolizidine alkaloid isolated from a marine sponge.

• 同義詞: Xestospongin C, Xestospongia sp., XeC
• 經驗公式（希爾表示法）: C₂₈H₅₀N₂O₂
• 分子量：: 446.71
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: film
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white to off-white
• 溶解度: DMSO: 1 mg/mL; ethanol: 1 mg/mL; methanol: 1 mg/mL
• 儲存溫度: −20°C

描述

一般說明

A macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry₁R). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the ER stores in a reversible manner.

An oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the endoplasmic reticulum stores in a reversible manner.

生化／生理作用

Primary Target
IP3-mediated Ca2+ release

Target IC₅₀: 358 nM in blocking IP3-mediated Ca2+ release

警告

Toxicity: Harmful (C)

準備報告

Sonication may be required to achieve complete solubilization.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Oka, T., et al. 2002. Br. J. Pharmacol.135, 1959.
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable