676491

VEGF Inducer, GS4012

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

• 同義詞: VEGF Inducer, GS4012, 4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012
• 經驗公式（希爾表示法）: C₁₄H₁₅NOS · xHCl
• CAS號碼: 328073-92-3
• 分子量：: 245.34 (free base basis)
• MDL號碼: MFCD00550210
• 分類程式碼代碼: 12352200
• NACRES: NA.51

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: DMSO: 200 mg/mL; methanol: 50 mg/mL; water: soluble
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: S(CCc2ccncc2)c1ccc(cc1)OC.Cl
• InChI: 1S/C14H15NOS.ClH/c1-16-13-2-4-14(5-3-13)17-11-8-12-6-9-15-10-7-12;/h2-7,9-10H,8,11H2,1H3;1H
• InChI 密鑰: CYZALCLQLHDAEC-UHFFFAOYSA-N

描述

一般說明

A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.

生化／生理作用

Cell permeable: yes

Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable