一般說明
An inactive compound that can be used as a negative control for inhibition of EGFR (IC50 >1250 μM for EGFR kinase). Has been shown to inhibit IL-2 stimulated Tyk-2 phosphorylation in ConA-activated T cells.
生化／生理作用
negative control for inhibition of EGFR
Target IC<SUB>50</SUB>:>1250 μM for EGFR kinase
Target IC<SUB>50</SUB>:>1250 μM for EGFR kinase
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
儲存類別代碼
10-13 - German Storage Class 10 to 13
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
J J Bright et al.
Journal of immunology (Baltimore, Md. : 1950), 162(10), 6255-6262 (1999-05-07)
IL-12 is a macrophage-derived cytokine that induces proliferation, cytokine production, and cytotoxic activity of T and NK cells. Signaling through its receptor, IL-12 induces these cellular responses by tyrosine phosphorylation and activation of Janus kinase-2 (Jak-2), Tyk-2, Stat3, and Stat4.
H Ruetten et al.
British journal of pharmacology, 122(1), 59-70 (1997-09-23)
1 Here we compared the effects of various inhibitors of the activity of protein tyrosine kinase on (i) the expression of the activity of the inducible isoform of nitric oxide (NO) synthase (iNOS) caused by endotoxin (lipopolysaccharide, LPS) in cultured
A Gazit et al.
Journal of medicinal chemistry, 32(10), 2344-2352 (1989-10-01)
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These competitive inhibitors
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