567806

Src Kinase Inhibitor II

The Src Kinase Inhibitor II, also referenced under CAS 459848-35-2, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 同義詞: Src Kinase Inhibitor II
• 經驗公式（希爾表示法）: C₂₂H₂₀N₄O₃S
• CAS號碼: 459848-35-2
• 分子量：: 420.48
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: pale orange
• 溶解度: DMSO: 20 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

描述

一般說明

A potent, selective, reversible, and ATP-competitive inhibitor of Src family tyrosine kinases (IC₅₀ = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR tyrosine kinase even at concentrations as high as 50 µM.

A substituted triazoloquinoline-1-thione compound that acts as a potent, ATP-competitive, reversible and selective inhibitor of Src family tyrosine kinases (IC₅₀ = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR even at concentrations as high as 50 µM.

生化／生理作用

Cell permeable: no

Primary Target
human recombinant Csk

Product competes with ATP.

Reversible: yes

Target IC₅₀: 1.2 µM for human recombinant Csk

包裝

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Kilimnik, A., et al. 2003. Cell. Mol. Biol. Lett.8, 588.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable