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產品名稱
Smad3抑制剂，SIS3, Smad3 Inhibitor, SIS3, CAS 1009104-85-1, is a cell-permeable, selective inhibitor of TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated signaling. Does not affect Smad2, MAPK, ERK, or PI3-K.
品質等級
化驗
≥90% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
off-white
溶解度
DMSO: 15 mg/mL
ethanol: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
[n]1(c2ncccc2c(c1c5ccccc5)C=CC(=O)N3CCc4c(cc(c(c4)OC)OC)C3)C
InChI
1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3
InChI 密鑰
IJYPHMXWKKKHGT-UHFFFAOYSA-N
應用
生化／生理作用
Smad3（SIS3）的特异性抑制剂是一种吡咯并吡啶化合物。[3]它选择性阻断转化生长因子（TGF）-β1-依赖型母体十肽同系物3 （Smad3） 磷酸化和Smad3介导的细胞途径，但是不影响Smad2, p38分裂素活化的蛋白质激酶（MAPK）、胞外信号调节激酶（ERK）或磷酸肌醇3-激酶（PI3K）信号传导。 [4][3] 通过其抑制功能， SIS3调节小鼠单侧输尿管梗阻（UUO）肾的纤维化、细胞凋亡和炎症。因此，SIS3可用作肾病抗纤维化治疗的有效药物。[5]
主要靶标
TGF-β1依赖性Smad3磷酸化和Smad3介导的细胞信号转导
TGF-β1依赖性Smad3磷酸化和Smad3介导的细胞信号转导
包裝
用惰性气体包装
警告
毒性：刺激性（B）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他說明
可逆：否
产物不与ATP竞争。
细胞可渗透性：是
Jinnin, M., et al. 2006.Mol.Pharmacol.69, 597.
产物不与ATP竞争。
细胞可渗透性：是
Jinnin, M., et al. 2006.Mol.Pharmacol.69, 597.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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