565749

β-Secretase Inhibitor II

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 同義詞: β-Secretase Inhibitor II, Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
• 經驗公式（希爾表示法）: C₂₅H₃₉N₃O₅
• CAS號碼: 263563-09-3
• 分子量：: 461.59
• MDL號碼: MFCD03453567
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N([C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O)C(=O)OCc1ccccc1
• InChI: 1S/C25H39N3O5/c1-16(2)12-20(14-29)26-23(30)21(13-17(3)4)27-24(31)22(18(5)6)28-25(32)33-15-19-10-8-7-9-11-19/h7-11,14,16-18,20-22H,12-13,15H2,1-6H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1

描述

一般說明

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.

A potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.

生化／生理作用

Cell permeable: yes

Primary Target
β-secretase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

Z-Val-Leu-Leu-CHO

重構

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

其他說明

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable