557403
RNA 聚合酶 III抑制剂
RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).
同義詞:
RNA 聚合酶 III抑制剂, ML-60218，N-[1-（3-（5-氯-3-甲基苯并[b]噻吩-2-基-1-甲基-1H-吡唑-5-基）]-2-氯苯磺酰胺
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品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
off-white
溶解度
DMSO: 15 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
InChI 密鑰
BVBDTTLISMIOJY-UHFFFAOYSA-N
一般說明
RNA聚合酶III(RNA Pol III)的细胞可渗透性抑制剂（对于人RNA Pol III的IC50=27 µM，对于酿酒酵母的RNA Pol III的IC50=32 µM）。通过阻止RNA Pol III介导的tRNA转录，来抑制酵母中的细胞生长。
一种对RNA聚合酶III具有广谱抑制活性的细胞可渗透性吲唑磺酰胺化合物(对于人和酿酒酵母RNA Pol III分别为IC50 = 27和32 µM）。通过阻止RNA Pol III介导的tRNA转录，来抑制酵母中的细胞生长。也可以25 mM的DMSO溶液（目录号557404）提供。
生化／生理作用
产物不与ATP竞争。
可逆：否
抗RNA聚合酶III的主要靶标
活性
活性
细胞可渗透性：是
靶标IC50：对于人为27M，对于酿酒酵母RNA Pol III为32 µM
包裝
用惰性气体包装
警告
毒性：致癌/致畸（D）
準備報告
可能需要稍微加热才能完全溶解。
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他說明
Wu, L., et al. 2003.Euk.Cell2, 256.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Jessica M Silva et al.
RNA biology, 8(3), 496-505 (2011-05-03)
More than 98% of the human genome is comprised of non-protein coding sequences. Interestingly, a considerable fraction of these sequences is transcribed into non-protein coding RNA transcripts. These transcripts range in size from very small RNAs such as the miRNAs
Magdalena Podlacha et al.
Nature communications, 15(1), 2274-2274 (2024-03-14)
One of the hopes for overcoming the antibiotic resistance crisis is the use of bacteriophages to combat bacterial infections, the so-called phage therapy. This therapeutic approach is generally believed to be safe for humans and animals as phages should infect
Kevin Van Bortle et al.
Nature communications, 13(1), 3007-3007 (2022-06-01)
RNA polymerase III (Pol III) includes two alternate isoforms, defined by mutually exclusive incorporation of subunit POLR3G (RPC7α) or POLR3GL (RPC7β), in mammals. The contributions of POLR3G and POLR3GL to transcription potential has remained poorly defined. Here, we discover that
Maiko Kitaoka et al.
Current biology : CB, 32(18), 3939-3951 (2022-08-17)
Although central to evolution, the causes of hybrid inviability that drive reproductive isolation are poorly understood. Embryonic lethality occurs when the eggs of the frog X. tropicalis are fertilized with either X. laevis or X. borealis sperm. We observed that distinct subsets of
Jeffrey Y Zhou et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(5), e2213777120-e2213777120 (2023-01-25)
The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to generate mature bioactive cytokine and gasdermin D which facilitates IL-1 release and
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