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Merck
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重要文件

557370

Sigma-Aldrich

咖马林

≥98% (HPLC), solid, PKC inhibitor, Calbiochem®

同義詞:

咖马林

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About This Item

經驗公式（希爾表示法）:
C30H28O8
CAS號碼:
82-08-6
分子量：:
516.54
MDL號碼:
MFCD00017361
分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

咖马林, A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC₅₀ = 3-6 µM) and PKCθ.

品質等級

100

描述

Merck USA index - 14, 8272

化驗

≥98% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze

顏色

orange

溶解度

ethanol: 1 mg/mL
DMSO: 30 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

O1C(C=Cc2c1c(c(c(c2O)Cc4c(c(c(c(c4O)C(=O)C)O)C)O)O)C(=O)\C=C\c3ccccc3)(C)C

InChI

1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+

InChI 密鑰

DEZFNHCVIZBHBI-ZHACJKMWSA-N

一般說明

一种可渗透细胞且可逆的蛋白激酶C抑制剂，其对PKCδ(IC50 = 3-6 µM)和PKCθ具有更高的选择性。抑制PKCα、PKCβ和PKCγ亚型，但效力显著降低（IC50=30-42 µM）。对PKCε、PKCη和PKCζ的抑制活性降低（IC50=80-100 µM）。还已知抑制CaM激酶III(IC50 = 5.3 µM)。
一种蛋白激酶Cδ（PKCδ，IC50=3-6 µM）和PKCΘ同工酶的细胞渗透性可逆抑制剂。也抑制PKCα、PKCβ和PKCγ亚型，但效力显著降低（IC50=30-42 µM）。对PKCε、PKCη和PKCξ的抑制活性降低（IC50=80-100 µM）。还已知抑制CaM激酶III（IC50 = 5.3 µM）。

生化／生理作用

主要靶标
PKCδ
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：对于PKCδ为3-6 µM；对于CaM激酶III为5.3 µM

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

其他說明

Villalba, M., et al. 1999.J. Immunol. 163, 5813.
Gschwendt, M., et al. 1994.Biochem.Biophys.Res. Commun.199, 93.
Gschwendt, M., et al. 1994.FEBS Lett.338, 85.
Gschwendt, M., et al. 1984.Cancer Lett.25, 177.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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