推薦產品
產品名稱
RAGE 拮抗剂, FPS-ZM1, RAGE Antagonist, FPS-ZM1, is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively, against Aβ40, HMGB1 & S100B, binding to sRAGE).
品質等級
化驗
≥98% (HPLC)
形狀
semisolid
viscous liquid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white to off-white
溶解度
DMSO: 100 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
O=C(C1=CC=C(Cl)C=C1)N(CC2=CC=CC=C2)C3CCCCC3
InChI
1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2
InChI 密鑰
XDFKWGIBQMHSOH-UHFFFAOYSA-N
一般說明
一种血脑屏障渗透性、无毒的叔酰胺化合物，作为RAGE（晚期糖基化终末产物受体）V结构域介导的配体结合的高亲和力、强效、多模式阻断剂（针对Aβ40、HMGB1和S100B，与sRAGE结合，Ki分别为25、148和230 nM）。阻断RAGE介导的Aβ40和Aβ42流入大脑。还显示出抑制Aβ-RAGE诱导的NF-κB激活和NF-κB-依赖性β-分泌酶转录。据报道，每日对APPsw/0小鼠AD模型（1 mg/kg/d，通过ip）进行治疗，可显著减少皮质和海马体中的硫黄素S阳性淀粉样斑块（减少70%至80%），并将认知能力恢复到非AD小鼠的水平。
生化／生理作用
主要靶标
RAGE
RAGE
可逆性：是
细胞可渗透性：是
靶标Ki：对A&beta分别为25、148和230 nM
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
其他說明
Deane, R., et al. 2012.J. Clin. Invest.122, 1377.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Chao Song et al.
Brain sciences, 12(5) (2022-05-29)
(1) Background: Chemotherapy-induced cognitive impairment (CICI) is often observed in cancer patients and impairs their life quality. Grape-seed-orientated procyanidin has been shown to have anti-inflammatory and neuroprotective effects, yet its effects in preventing CICI have not been investigated. (2) Method:
Roberta Angioni et al.
Cell reports. Medicine, 4(11), 101266-101266 (2023-11-10)
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has fueled the COVID-19 pandemic with its enduring medical and socioeconomic challenges because of subsequent waves and long-term consequences of great concern. Here, we chart the molecular basis of COVID-19
Han-Kyul Nam et al.
Biological & pharmaceutical bulletin, 44(11), 1697-1706 (2021-11-02)
Advanced glycation end products (AGEs) are the products formed through a non-enzymatic reaction of reducing sugars with proteins or lipids. There is a potential for toxicity in the case of AGEs produced through glycation with dicarbonyl compounds including methylglyoxal, glyoxal
Yidi Wu et al.
American journal of physiology. Lung cellular and molecular physiology, 319(1), L185-L195 (2020-05-21)
S100A4 is a low-molecular-mass (12 kDa) EF-hand Ca2+-binding S100 protein that is expressed in a broad range of normal tissue and cell types. S100A4 can be secreted from some cells to act in an autocrine or paracrine fashion on target
Vijayasree V Giridharan et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(1), 640-653 (2020-09-05)
Pneumococcal meningitis is a life-threatening infection of the central nervous system (CNS), and half of the survivors of meningitis suffer from neurological sequelae. We hypothesized that pneumococcal meningitis causes CNS inflammation via the disruption of the blood-brain barrier (BBB) and
Active Filters
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務
