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Merck
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文件

539741

Sigma-Aldrich

PTP1B抑制剂

PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively).

同義詞:

PTP1B抑制剂

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About This Item

經驗公式（希爾表示法）:
C26H19Br2N3O7S3
CAS號碼:
765317-72-4
分子量：:
741.45
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥95% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 100 mg/mL
ethanol: 5 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

InChI

1S/C26H19Br2N3O7S3/c1-2-21-23(24(32)14-11-19(27)25(33)20(28)12-14)18-8-7-17(13-22(18)38-21)41(36,37)30-15-3-5-16(6-4-15)40(34,35)31-26-29-9-10-39-26/h3-13,30,33H,2H2,1H3,(H,29,31)

InChI 密鑰

SXKBTDJJEQQEGE-UHFFFAOYSA-N

一般說明

一种PTP1B的细胞渗透性、选择性、可逆和非竞争性变构抑制剂（PTP1B403和PTP1B298的IC50 分别为4 µM和8 µM）。结合到远离催化口袋的新位点，并通过阻止WPD环闭合来抑制PTP1B活性。也可提供InSolution格式（目录号539749。

生化／生理作用

主要靶标
PTP1B403
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：对于PTP1B403和PTP1B298分别为4 µM和8 µM。

包裝

用惰性气体包装

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。

其他說明

Wiesmann, C., et al. 2004.Nat. Struct.Mol.Biol.11, 730.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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