5.05315

A 438079

• 同義詞: A 438079, 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride, P2X7 Purinergic Receptor Antagonist, A 438079, A438079, A-438079
• 經驗公式（希爾表示法）: C₁₃H₉Cl₂N₅ · xHCl
• CAS號碼: 899507-36-9
• 分子量：: 306.15 (free base basis)
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 100 mM
• 儲存溫度: 2-8°C
• InChI: 1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H
• InChI 密鑰: MBTJFFMIPPMRGR-UHFFFAOYSA-N

描述

一般說明

A potent, competitive, and selective antagonist of P2X₇ purinergic receptor (pIC₅₀ = 6.5 nM and 6.9 nM for rat and human P2X₇ receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10 µM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC₅₀ = 100 and 300 nM at rat and human P2X₇ receptors, respectively.

生化／生理作用

Primary Target
P2X₇

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Donnelly-Roberts, et al., 2007, Br. J. Pharmacol.101, 571.

Wang B, et al., 2013, Purinergic Signal.9, 101.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable