推薦產品
product name
MMP-12抑制剂，MMP408, The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
品質等級
化驗
≥94% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
off-white
溶解度
DMSO: 100 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
一般說明
一种二苯并呋喃基磺酰胺基缬氨酸化合物，可作为有效的活性位点锌靶向MMP-12选择性抑制剂（对人MMP-12的IC50 =2 nM），对小鼠/大鼠/绵羊物种的MMP-12（分别为IC50=160、320和22.3 nM）或人MMP-3/13/14（分别为IC50=351、120和1100 nM）的活性弱得多，并且对人Agg-1/2（IC50 >5 µM），TACE（IC50 >25 µM）和MMP-1/7（IC50 >6 µM）几乎无效。MMP408在小鼠中具有口服活性，并显示可有效减轻rhMMP-12诱导的小鼠体内肺组织炎症反应超过50%（5 mg/kg，p.o.，b.i.d.）。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他說明
Li, W., et al. 2009.J. Med. Chem.52, 1799.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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iScience, 24(10), 103201-103201 (2021-10-28)
Respiratory syncytial virus (RSV) infection often exacerbates bronchial asthma, but there is no licensed RSV vaccine or specific treatments. Here we show that RSV-induced alveolar macrophages, which produce high levels of matrix metalloproteinase-12 (MMP-12), exacerbate allergic airway inflammation with increased
Caijiao Yi et al.
Journal of neuroinflammation, 19(1), 78-78 (2022-04-07)
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Meghali Nighot et al.
Journal of Crohn's & colitis, 15(10), 1751-1765 (2021-04-10)
Matrix metalloproteinases [MMPs] play an important role in extracellular matrix regulation during cell growth and wound healing. Increased expression of MMP-12 [human macrophage elastase] has been reported in inflammatory bowel disease [IBD] which is characterised by the loss of epithelial
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Cell reports, 36(2), 109363-109363 (2021-07-15)
Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclear. Both WT and mutant proteins
相關內容
Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
根據您的需求選擇不同類型的蛋白酶抑制劑，防止蛋白質在分離和表徵過程中降解，保障樣品預備過程中蛋白質的安全。
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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