438186

Lovastatin sodium salt

≥95% (HPLC), solid, L-type calcium channel blocker, Calbiochem^®

• 同義詞: Lovastatin, Sodium Salt, L-Type Calcium Channel Blocker IV
• 經驗公式（希爾表示法）: C₂₄H₃₇O₆ · Na
• 分子量：: 444.54
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• product name: Lovastatin, Sodium Salt, Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.
• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: off-white
• 溶解度: DMSO: 100 mg/mL; ethanol: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.

Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21^ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G₁ phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.

生化／生理作用

Cell permeable: yes

Primary Target
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

重構

Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.

其他說明

Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA96, 7197.
Carel, K., et al. 1996. J. Biol. Chem.271, 30625.
McGuire, T.F., et al. 1996. J. Biol. Chem.271, 27402.
Umetani, N., et al. 1996. Biochim. Biophys. Acta1303, 199.
Xu, X.Q., et al. 1996. Arch. Biochem. Biophys.326, 233.
Reusch, J.E.-B., et al. 1995. J. Biol. Chem.270, 2036.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable