341251

Fascaplysin, Synthetic

A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM).

• 同義詞: Fascaplysin, Synthetic
• 經驗公式（希爾表示法）: C₁₈H₁₁ClN₂O
• CAS號碼: 114719-57-2
• 分子量：: 306.75
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (NMR)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: brown
• 溶解度: methanol: 1 mg/mL; DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H
• InChI 密鑰: PWUOOJVYZQILBG-UHFFFAOYSA-N

描述

一般說明

A cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC₅₀ = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk′s (IC₅₀ >20 µM) and tyrosine kinases (IC₅₀ >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.

生化／生理作用

Cell permeable: yes

Primary Target
CDK4/D1

Product competes with ATP.

Reversible: yes

Target IC₅₀: 0.35 µM against Cdk4/D1

包裝

Packaged under inert gas

警告

Toxicity: Toxic (F)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Hormann, A., et al. 2001. Bioorg. Med. Chem.9, 917.
Kirsch, G., et al. 2000. J. Nat. Prod.63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable