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重要文件

329600

Sigma-Aldrich

Erastin

≥98% (HPLC), solid, antitumor agent, Calbiochem®

同義詞:

Erastin, 2-(1-(4-(2-(4-氯苯氧基)乙酰基)-哌嗪-1-基)-乙基)-3-(2-乙氧基苯基)-3H-喹唑啉-4-酮

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About This Item

經驗公式(希爾表示法):
C30H31ClN4O4
CAS號碼:
分子量::
547.04
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

產品名稱

Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

品質等級

化驗

≥98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 50 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

Clc1ccc(cc1)OCC(=O)N2CCN(CC2)C(C)c3[n]([c](c5c(n3)cccc5)=O)c4c(cccc4)OCC

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI 密鑰

BKQFRNYHFIQEKN-UHFFFAOYSA-N

一般說明

具有致癌基因选择性杀伤力的细胞可渗透的哌嗪基-喹唑啉酮化合物。显示结合线粒体电压依赖性阴离子通道(VDAC)并改变其门控;在几种人类肿瘤中快速诱导氧化性,非凋亡性细胞死亡,这些肿瘤在RAS-RAF-MEK信号传导中具有激活突变(在BJ-TERT/LT/ST/RASV12细胞中EC50 = 6.0 µM)。

包裝

用惰性气体包装

警告

毒性:标准处理(A)

重構

复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多6个月。

其他說明

Yagoda, N., et al. 2007.Nature447, 864.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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