324623

Eg5 Inhibitor IV, VS-83

The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 同義詞: Eg5 Inhibitor IV, VS-83, 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
• 經驗公式（希爾表示法）: C₁₄H₁₁FN₂OS
• CAS號碼: 909250-29-9
• 分子量：: 274.31
• MDL號碼: MFCD28138121
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: ethanol: 5 mg/mL; DMSO: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: Fc1c2c(ccc1)NC(=S)NC2c3cc(ccc3)O
• InChI: 1S/C14H11FN2OS/c15-10-5-2-6-11-12(10)13(17-14(19)16-11)8-3-1-4-9(18)7-8/h1-7,13,18H,(H2,16,17,19)
• InChI 密鑰: MAEYCDNDKNPNQJ-UHFFFAOYSA-N

描述

一般說明

A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC₅₀ = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC₅₀ = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Muller, C., et al. 2007. Cancer Chemother. Pharmacol.59, 157.
Santamaria, A., et al. 2007. Mol. Biol. Cell18, 4024.
Sarli, V., et al. 2005. ChemBioChem6, 2005.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable