287840

Diclofenac Sodium

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

• 同義詞: Diclofenac Sodium, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
• 經驗公式（希爾表示法）: C₁₄H₁₀Cl₂NO₂ · Na
• CAS號碼: 15307-79-6
• 分子量：: 318.13
• MDL號碼: MFCD00082251
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 描述: Merck USA index - 14, 3081
• 化驗: ≥98% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: water: 25 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 10-30°C
• SMILES 字串: [Na+].Clc1c(c(ccc1)Cl)Nc2c(cccc2)CC(=O)[O-]
• InChI: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• InChI 密鑰: KPHWPUGNDIVLNH-UHFFFAOYSA-M

描述

一般說明

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC₅₀ = 9.5 µM).

A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC₅₀ = 76 nM) and COX-2 (IC₅₀ = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC₅₀ ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.

生化／生理作用

Cell permeable: yes

Primary Target
COX-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重構

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res.45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06,GHS08,GHS09
• 訊號詞: Danger
• 危險聲明: H301,H361d,H372,H411
• 防範說明: P202 - P260 - P264 - P273 - P280 - P301 + P310
• 危險分類: Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable