234109-M

Colcemid

Cell synchronization agent.

• 同義詞: Colcemid, Demecolcine
• 經驗公式（希爾表示法）: C₂₁H₂₅NO₅
• CAS號碼: 477-30-5
• 分子量：: 371.43
• MDL號碼: MFCD00075459
• 分類程式碼代碼: 12352200

屬性

• 描述: Merck USA index - 14, 2887
• 化驗: ≥98% (HPLC)
• 形狀: crystalline powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 溶解度: chloroform: 10 mg/mL; ethanol: soluble
• 儲存溫度: 10-30°C
• SMILES 字串: N(C1CCc2c(c(c(c(c2)OC)OC)OC)C3=CC=C(C(=O)C=C31)OC)C
• InChI: 1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
• InChI 密鑰: NNJPGOLRFBJNIW-UHFFFAOYSA-N

描述

一般說明

Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.

Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.

生化／生理作用

Primary Target
Depolymerizes microtubules and limits microtubule formation.

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重構

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.

其他說明

Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany