233501-M

Coagulation Factor XIII, Human Plasma

Coagulation Factor XIII, Human Plasma, CAS 9013-56-3, is a native tetrameric form composed of two identical α- and two β-subunits. Thrombin converts the α2β2 tetramer to a modified α2ʹβ2 tetramer.

• 同義詞: Coagulation Factor XIII, Human Plasma, Fibrin-stabilizing Factor
• CAS號碼: 9013-56-3
• MDL號碼: MFCD00005925
• 分類程式碼代碼: 12352202

屬性

• 品質等級: 100
• 描述: Merck USA index - 14, 3926
• 化驗: ≥95% (SDS-PAGE)
• 形狀: liquid
• 比活性: ≥40 units/mg protein (clotting assay)
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 儲存溫度: −20°C

描述

一般說明

Native coagulation factor XIII from human plasma. Plasma Factor XIII is a tetramer (α₂β₂) composed of two identical α-subunits and two identical β-subunits. After thrombin cleavage converts the α₂β₂ tetramer to a modified α₂′β₂ tetramer, Ca²⁺ promotes both the dissociation of the β₂ dimer and the activation of the α₂′ dimer to its catalytically active form. This activated Factor XIII (Factor XIIIa) strengthens the fibrin clot by catalyzing the formation of glutamyl-lysine bonds between fibrin monomers.

警告

Toxicity: Standard Handling (A)

單位定義

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma. One unit is defined as the activity in 1 ml of normal, pooled plasma.

外觀

In 500 µM EDTA, 50% glycerol.

準備報告

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

重構

Following initial thaw, aliquot and freeze (-20°C).

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2