23-034-M
p53 Protein, 10 µg
Full length, recombinant human p53. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.
同義詞:
Cellular tumour antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumour suppressor p53, TP53
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About This Item
分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.41
推薦產品
生物源
human
品質等級
重組細胞
expressed in E. coli
形狀
liquid
製造商／商標名
Upstate®
技術
activity assay: suitable
溶解度
water: soluble
GenBank登錄號
儲存溫度
−70°C
基因資訊
human ... TP53(120407068)
一般說明
Research area: Apoptosis
N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli. The p53 protein is a tumor suppressor encoded by TP53 gene located on chromosome 17.
N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli. The p53 protein is a tumor suppressor encoded by TP53 gene located on chromosome 17.
應用
Ubiquitination Cascade Comoponent: Substrate
生化／生理作用
p53 is expressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest, depending on the physiological circumstances and the cell type. Defects in p53 expression have been implicated in several diseases, including choroid plexus papilloma, lung cancer, head/neck squamous cell carcinomas, oesophageal squamous cell carcinoma, Li-Fraumeni syndrome, and hereditary adrenocortical carcinoma.
外觀
Purified using immobilized metal affinity chromatography.
其他說明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律資訊
GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Hany E Marei et al.
Cancer cell international, 21(1), 703-703 (2021-12-26)
The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, including those of the breast
The p53 tumor suppressor protein
Genes & diseases (1998)
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