220467

2-Chloro-2′-deoxyadenosine

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

• 同義詞: 2-Chloro-2′-deoxyadenosine, 2CdA, Cladribine
• 經驗公式（希爾表示法）: C₁₀H₁₂ClN₅O₃
• CAS號碼: 4291-63-8
• 分子量：: 285.69
• MDL號碼: MFCD00153939
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
• InChI 密鑰: PTOAARAWEBMLNO-KVQBGUIXSA-N

描述

一般說明

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.

生化／生理作用

Cell permeable: no

Primary Target
Antileukemic and immunosuppressive activity

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

其他說明

Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H301,H341,H361fd,H372
• 防範說明: P202 - P260 - P264 - P280 - P301 + P310 - P405
• 危險分類: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable