218710

Casein Kinase II Inhibitor III, TBCA

The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 同義詞: Casein Kinase II Inhibitor III, TBCA, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
• 經驗公式（希爾表示法）: C₉H₄Br₄O₂
• CAS號碼: 934358-00-6
• 分子量：: 463.74
• MDL號碼: MFCD20921901
• 分類程式碼代碼: 12352200
• NACRES: NA.54

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 效力: 110 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 10 mg/mL (Use only fresh DMSO.); ethanol: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: Brc1c(c(cc(c1Br)\C=C\C(=O)O)Br)Br
• InChI: 1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
• InChI 密鑰: SVJQCVOKYJWUBC-OWOJBTEDSA-N

描述

一般說明

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).

生化／生理作用

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target K_i: 77 nM against Casein Kinase II

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

其他說明

Pagano, M.A., et al. 2006. Chembiochem8, 129

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2